Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity

Impaired glucose homeostasis and energy balance are integral to the pathophysiology of diabetes and obesity. Here we show that administration of a glycine transporter 1 (GlyT1) inhibitor, or molecular GlyT1 knockdown, in the dorsal vagal complex (DVC) suppresses glucose production, increases glucose tolerance and reduces food intake and body weight gain in healthy, obese and diabetic rats. These findings provide proof of concept that GlyT1 inhibition in the brain improves glucose and energy homeostasis. Considering the clinical safety and efficacy of GlyT1 inhibitors in raising glycine levels in clinical trials for schizophrenia, we propose that GlyT1 inhibitors have the potential to be repurposed as a treatment of both obesity and diabetes

Therapy: Metformin takes a new route to clinical efficacy.

International audienceMetformin is currently the first-line treatment option for patients with type 2 diabetes mellitus, yet its mechanism of action remains uncertain. A new study reveals the important role for the activation of a duodenal AMPK-dependent neuronal pathway in the acute antihyperglycaemic effect of metformin and the inhibition of hepatic glucose production

Dual Identities inside the Gluon and the Graviton Scattering Amplitudes

Recently, Bern, Carrasco and Johansson conjectured dual identities inside the gluon tree scattering amplitudes. In this paper, we use the properties of the heterotic string and open string tree scattering amplitudes to refine and derive these dual identities. These identities can be carried over to loop amplitudes using the unitarity method. Furthermore, given the $M$-gluon (as well as gluon-gluino) tree amplitudes, $M$-graviton (as well as graviton-gravitino) tree scattering amplitudes can be written down immediately, avoiding the derivation of Feynman rules and the evaluation of Feynman diagrams for graviton scattering amplitudes.Comment: 43 pages, 3 figures; typos corrected, a few points clarified

The Momentum Kernel of Gauge and Gravity Theories

We derive an explicit formula for factorizing an $n$-point closed string amplitude into open string amplitudes. Our results are phrased in terms of a momentum kernel which in the limit of infinite string tension reduces to the corresponding field theory kernel. The same momentum kernel encodes the monodromy relations which lead to the minimal basis of color-ordered amplitudes in Yang-Mills theory. There are interesting consequences of the momentum kernel pertaining to soft limits of amplitudes. We also comment on surprising links between gravity and certain combinations of kinematic and color factors in gauge theory.Comment: 19 pages, 1 figur

Monodromy--like Relations for Finite Loop Amplitudes

We investigate the existence of relations for finite one-loop amplitudes in Yang-Mills theory. Using a diagrammatic formalism and a remarkable connection between tree and loop level, we deduce sequences of amplitude relations for any number of external legs.Comment: 24 pages, 6 figures, v2 typos corrected, reference adde

Space-like (vs. time-like) collinear limits in QCD: is factorization violated?

We consider the singular behaviour of QCD scattering amplitudes in kinematical configurations where two or more momenta of the external partons become collinear. At the tree level, this behaviour is known to be controlled by factorization formulae in which the singular collinear factor is universal (process independent). We show that this strict (process-independent) factorization is not valid at one-loop and higher-loop orders in the case of the collinear limit in space-like regions (e.g., collinear radiation from initial-state partons). We introduce a generalized version of all-order collinear factorization, in which the space-like singular factors retain some dependence on the momentum and colour charge of the non-collinear partons. We present explicit results on one-loop and two-loop amplitudes for both the two-parton and multiparton collinear limits. At the level of square amplitudes and, more generally, cross sections in hadron--hadron collisions, the violation of strict collinear factorization has implications on the non-abelian structure of logarithmically-enhanced terms in perturbative calculations (starting from the next-to-next-to-leading order) and on various factorization issues of mass singularities (starting from the next-to-next-to-next-to-leading order).Comment: 81 pages, 5 figures, typos corrected in the text, few comments added and inclusion of NOTE ADDED on recent development

Multi-gluon helicity amplitudes with one off-shell leg within high energy factorization

Basing on the Slavnov-Taylor identities, we derive a new prescription to obtain gauge invariant tree-level scattering amplitudes for the process g*g->Ng within high energy factorization. Using the helicity method, we check the formalism up to several final state gluons, and we present analytical formulas for the the helicity amplitudes for N=2. We also compare the method with Lipatov's effective action approach.Comment: 25 pages, quite a few figures, an appendix added, typos correcte

On tree amplitudes with gluons coupled to gravitons

In this paper, we study the tree amplitudes with gluons coupled to gravitons. We first study the relations among the mixed amplitudes. With BCFW on-shell recursion relation, we will show the color-order reversed relation, $U(1)$-decoupling relation and KK relation hold for tree amplitudes with gluons coupled to gravitons. We then study the disk relation which expresses mixed amplitudes by pure gluon amplitudes. More specifically we will prove the disk relation for mixed amplitudes with gluons coupled to one graviton. Using the disk relation and the properties of pure gluon amplitudes, the color-order reversed relation, $U(1)$-decoupling relation and KK relation for mixed amplitudes can also be proved. Finally, we give some brief discussions on BCJ-like relation for mixed amplitudes.Comment: 33pages,no figur

Tree amplitudes and color decomposition in broken SU(2)

We propose a color decomposition for general tree amplitudes in a SU(2) gauge theory which is spontaneously broken via the Higgs mechanism. Working in the unitary gauge, we construct color-ordered amplitudes by explicitly presenting a set of color-ordered Feynman rules. Those primitive amplitudes are gauge-invariant, and they preserve perturbative unitarity in the high-energy limit. Serving as building blocks of color-dressed tree amplitudes, they allow for efficient evaluation of tree-level scattering amplitudes involving gauge bosons and the Higgs boson via the Berends-Giele recursion relations for color-ordered currents. We demonstrate the efficiency of this computational scheme by calculating on-shell amplitudes for scattering of five, six and nine W-bosons in the limit of vanishing Weinberg angle.Comment: 31 pages, 11 figure